IGM-7354, AN ANTI-PD-L1/IL-15 IGM IMMUNOCYTOKINE, ACTIVATES AND EXPANDS NK CELLS AND EFFECTOR MEMORY CD8+ T CELLS IN VIVO

被引：0

作者：

Desbois, Melanie ^{[1
]}

Giffon, Thierry ^{[1
]}

Yakkundi, Poonam ^{[1
]}

Pandey, Sivani ^{[1
]}

Rosete, Rodnie ^{[1
]}

Machado, Daniel ^{[1
]}

Manlusoc, Marigold ^{[1
]}

Calhoun, Susan ^{[1
]}

Kothambawala, Tasnim ^{[1
]}

Ananta, Jey ^{[1
]}

Koyama, Kristina ^{[1
]}

Cao, Yuan ^{[1
]}

Ng, Dean ^{[1
]}

Miranda-Katz, Tomas ^{[1
]}

Saini, Avneesh ^{[1
]}

Jain, Abhinav ^{[1
]}

Yue, Hongjun ^{[1
]}

Cai, Yang ^{[1
]}

Oyasu, Miho ^{[1
]}

Bogaert, Liz ^{[1
]}

Funke, Roel ^{[1
]}

Hernandez, Genevive ^{[1
]}

Nagata, Denise ^{[1
]}

Leabman, Maya ^{[1
]}

Humke, Eric ^{[1
]}

Carroll, Stephen ^{[1
]}

Wang, Beatrice ^{[1
]}

Keyt, Bruce ^{[1
]}

Sinclair, Angus ^{[1
]}

Kotturi, Maya ^{[1
]}

机构：

[1] IGM Biosci Inc, Mountain View, CA USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷

关键词：

D O I：

10.1136/jitc-2022-SITC2022.1215

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1215

引用

页码：A1260 / A1260

页数：1

共 50 条

[31] IL-15 activates telomerase and preserves telomere length in long term cultured memory CD8+T cells
Zhi, W
Li, Y
Weng, NP
FASEB JOURNAL, 2004, 18 (05): : A799 - A799
[32] A joint role for IL-2 and IL-15 in the differentiation and survival of short-lived effector and effector memory CD8+T cells
Williams, Matthew A.
Mitchell, Diana M.
Ravkov, Eugene V.
JOURNAL OF IMMUNOLOGY, 2009, 182
[33] CD8 T cells inhibit the IL-15 induced expansion of effector cells and the cytotoxic activity of NK cells toward tumour cells in the prostate cancer microenvironment
Elhage, O.
Sakellariou, C. A.
Smith, R. A. G.
Galustian, C.
Dasgupta, P.
BJU INTERNATIONAL, 2015, 115 : 70 - 71
[34] IL-15 inhibits IL-7Rα expression by memory-phenotype CD8+ T cells in the bone marrow
Quinci, Angela C.
Vitale, Sara
Parretta, Elisabetta
Soriani, Alessandra
Iannitto, Maria L.
Cippitelli, Marco
Fionda, Cinzia
Bulfone-Paus, Silvia
Santoni, Angela
Di Rosa, Francesca
EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (05) : 1129 - 1139
[35] Inhibition of Tumor Growth by NK1.1+ Cells and CD8+ T Cells Activated by IL-15 through Receptor β/Common γ Signaling in trans
Rowley, Jesse
Monie, Archana
Hung, Chien-Fu
Wu, T. -C.
JOURNAL OF IMMUNOLOGY, 2008, 181 (12): : 8237 - 8247
[36] Administration of IL-2 and IL-18 with anti-PD-L1 Ab suppresses liver tumor by early memory CD8 T cells
Kimura, Kiminori
Tanaka, Yoshimasa
Kohara, Michinori
CANCER SCIENCE, 2024, 115 : 1597 - 1597
[37] Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells
Sanjabi, Shomyseh
Mosaheb, Munir M.
Flavell, Richard A.
IMMUNITY, 2009, 31 (01) : 131 - 144
[38] IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
Mueller, YM
Makar, V
Bojczuk, PM
Witek, J
Katsikis, PD
INTERNATIONAL IMMUNOLOGY, 2003, 15 (01) : 49 - 58
[39] IL-15 promotes the survival of naive and memory phenotype CD8+ T cells (vol 170, pg 5018, 2003)
Berard, M
Brandt, K
Paus, SB
Tough, DF
JOURNAL OF IMMUNOLOGY, 2003, 171 (04): : 2170 - 2170
[40] Recombinant human IL-15 (rhlL-15) in combination with anti-PD-L1(Avelumab) in SIV infected rhesus macaques leads to the expansion of a subset of CXCR3+PD1-/low CD8 T cells
Moussa, Maha
Cheng, Jie
Chen, Ping
Chen, Hui
Li, Tong
Qin, Jing
Lifson, Jeffrey D.
Sneller, Michael C.
Krymskaya, Ludmila
Godin, Steven
Lane, Clifford
Catalfamo, Marta
JOURNAL OF IMMUNOLOGY, 2019, 202 (01):

← 1 2 3 4 5 →