Regioselective synthesis of substituted cyclohexa-1,3-dienes via the base-mediated cyclisation of α,β-unsaturated carbonyl compounds and γ-phosphonylcrotonates

被引：2

作者：

Joshi, Prabhakar R. ^{[1
]}

Chandra, Rajesh ^{[1
]}

Menon, Rajeev S. ^{[2
]}

机构：

[1] CSIR, Crop Protect Div, Indian Inst Chem Technol, Hyderabad 500007, India

[2] Cent Univ Haryana, Dept Chem, Jant Pali Mahendergarh 123031, Haryana, India

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 39期

关键词：

Cyclohexadiene; 3+3] benzannulation; Wadsworth Emmons reaction; Crotonates; Phosphonates; 3+3 BENZANNULATION REACTIONS; 2+2+2 CYCLOADDITION; IRREVERSIBLE INHIBITION; ACID TRANSAMINASE; 1,3-CYCLOHEXADIENE; ALDEHYDES;

D O I：

10.1016/j.tetlet.2020.152380

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The base-mediated reaction of alpha,beta-unsaturated carbonyl compounds and gamma-phosphonylcrotonates under an argon atmosphere readily furnishes substituted cyclohexa-1,3-dienes. The cyclisation proceeds with complete regioselectivity to afford products that are readily amenable to further redox manipulations. The presented method allows the rapid and regioselective syntheses of six-membered carbocycles at three different oxidation levels. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：3

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