Capped antithrombin III dosing is cost effective in the management of asparaginase-associated thrombosis

被引：2
|
作者：
Young, Jennifer [1 ]
Sawyer, Jaclyn [1 ]
Jenkins, Meredith [1 ]
O'Brien, Maureen [2 ,3 ]
Luchtman-Jones, Lori [3 ,4 ]
Breese, Erin H. [2 ,3 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Div Pharm, 3333 Burnet Ave,MLC 15010, Cincinnati, OH 45209 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Oncol, Canc & Blood Dis Inst, Cincinnati, OH 45209 USA
[3] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA
[4] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Div Hematol, Cincinnati, OH 45209 USA
来源：
PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 06期
关键词：
antithrombin III; asparaginase-induced thrombosis; capped antithrombin III; ACUTE LYMPHOBLASTIC-LEUKEMIA; VENOUS THROMBOEMBOLISM; SUPPLEMENTATION;
D O I：
10.1002/pbc.27719
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Asparaginase therapy induces a transient antithrombin III (ATIII) deficiency, which contributes to the risk of asparaginase-induced thrombosis. At Cincinnati Children's Hospital Medical Center, management of asparaginase-induced thrombosis includes ATIII supplementation during therapeutic anticoagulation with enoxaparin. Due to the expense associated with ATIII, a capped dosing approach for ATIII was evaluated in this population. Peak ATIII levels were obtained following capped doses to evaluate response. In this pilot evaluation, 11 patients received a total of 138 capped doses for a total cost savings of $803 782. This pilot evaluation represents the first reported analysis of capped ATIII dosing in oncology patients.
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页数：3
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