Total syntheses of (±)-cis-trikentrin A and (±)-cis-trikentrin B via electrocyclic ring closures of 2,3-divinylpyrrolines

被引：40
|
作者：
Huntley, Raymond J. [1 ]
Funk, Raymond L. [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 15期
关键词：
D O I：
10.1021/ol061259a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent and versatile strategy for the diastereoselective syntheses of (+/-)-cis-trikentrin A and B in 10 and 12 steps, respectively, from commercially available N-BOC-2-pyrrolidinone is described. The key step in each of the total syntheses is the construction of the central benzene ring via a facile 6 pi-electrocyclic ring closure of an appropriately substituted 2,3-divinylpyrroline, in turn, readily available by a Stille coupling reaction.
引用
收藏
页码：3403 / 3406
页数：4
相关论文
共 32 条
1234