Androgen deprivation causes up-regulation of androgen receptor transcript in the rat prostate

被引：7
|
作者：
Kumar, VL [1 ]
Majumder, PK [1 ]
Kumar, V [1 ]
机构：
[1] INT CTR GENET ENGN & BIOTECHNOL,VIROL GRP,NEW DELHI 110067,INDIA
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1997年 / 171卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
androgen receptor; mRNA; prostate; androgen deprivation; receptor regulation;
D O I：
10.1023/A:1006805503284
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have studied the effect of androgenic deprivation on the level of androgen receptor transcript in the rat ventral prostate. The rats were treated with estradiol benzoate, flutamide and [D Trp(6), des Gly(10)]gonadotropin releasing hormone (GnRH) for different time periods. These treatments produced a significant decrease in the weight of prostate. Total RNA isolated from the ventral prostates was hybridized with the cDNA probe for androgen receptor. Densitometric analysis of the autoradiographic signal revealed a rise in the level of androgen receptor RNA following treatment of rats with estradiol benzoate and flutamide. Treatment of rats with [D Trp(6), des Gly(10)] GnRH brought about a transient rise in the level of androgen receptor RNA. Thus, our results indicate that androgenic deprivation up-regulates the level of androgen receptor transcript.
引用
收藏
页码：133 / 138
页数：6
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