Tuning microenvironments: Induction of regulatory T cells by dendritic cells

被引：205
|
作者：
Belkaid, Yasmine [1 ]
Oldenhove, Guillaume [1 ]
机构：
[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, Bethesda, MD 20894 USA
来源：
IMMUNITY | 2008年 / 29卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.immuni.2008.08.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The body requires the generation of regulatory T (Treg) cells to preserve its integrity. Each microenvironment is controlled by a specific set of regulatory elements that have to be finefrly and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes or tumors. Various populations of dendritic cells (DCs) are central to the orchestration of this control. In this review, we will discuss some new findings associating DCs from defined compartments with the induction of antigen-specific Treg cells.
引用
收藏
页码：362 / 371
页数：10
相关论文
共 50 条
  • [31] The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance
    Zanoni, Ivan
    Granucci, Francesca
    AUTOIMMUNITY, 2011, 44 (01) : 23 - 32
  • [32] Optimizing Induction of CD8+Regulatory T Cells by Allogeneic Human Plasmacytoid Dendritic Cells
    Boor, P. P.
    Mancham, S.
    van der Laan, L. W.
    Metselaar, H. J.
    Kwekkeboom, J.
    TRANSPLANTATION, 2012, 94 (10) : 310 - 310
  • [33] Optimizing induction of CD8+regulatory T cells by allogeneic human plasmacytoid dendritic cells
    Boor, P.
    Mancham, S.
    van der Laan, L. J. W.
    Metselaar, H. J.
    Kwekkeboom, J.
    IMMUNOLOGY, 2012, 137 : 152 - 153
  • [34] Induction of CD4+regulatory T cells by IL-10-modulated dendritic cells
    Gregori, Silvia
    Serafini, Giorgia
    Tresoldi, Eleonora
    Bacchetta, Rosa
    Tomasoni, Daniela
    Roncarolo, Maria-Grazia
    JOURNAL OF IMMUNOLOGY, 2006, 176 : S216 - S216
  • [35] Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells
    Jones, Andrew
    Bourque, Jessica
    Kuehm, Lindsey
    Opejin, Adeleye
    Teague, Ryan M.
    Gross, Cindy
    Hawiger, Daniel
    IMMUNITY, 2016, 45 (05) : 1066 - 1077
  • [36] Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells
    Jangpatarapongsa, Kulachart
    Chootong, Patchanee
    Sattabongkot, Jetsumon
    Chotivanich, Kesinee
    Sirichaisinthop, Jeeraphat
    Tungpradabkul, Sumalee
    Hisaeda, Hajime
    Troye-Blomberg, Marita
    Cui, Liwang
    Udomsangpetch, Rachanee
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (10) : 2697 - 2705
  • [37] Induced regulatory T cells in inhibitory microenvironments created by cancer
    Whiteside, Theresa L.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (10) : 1411 - 1425
  • [38] Induction of regulatory properties in dendritic cells by Vα14 NKT cells
    Kojo, S
    Seino, K
    Harada, M
    Watarai, H
    Wakao, H
    Uchida, T
    Nakayama, T
    Taniguchi, M
    JOURNAL OF IMMUNOLOGY, 2005, 175 (06): : 3648 - 3655
  • [39] Autophagy in dendritic cells promotes atheroprotective regulatory T cells
    Clement, Marc
    Raffort, Juliette
    Lareyre, Fabien
    Mallat, Ziad
    M S-MEDECINE SCIENCES, 2021, 37 (03): : 216 - 218
  • [40] REGULATORY T CELLS Fine-tuning TReg cells
    David, Rachel
    NATURE REVIEWS IMMUNOLOGY, 2009, 9 (04) : 226 - 226
12345