ULTRASOUND WITH MICROBUBBLE CONTRAST AGENT AND UROKINASE FOR THROMBOSIS

被引：7
|
作者：
Wang, Fangfang [1 ]
Shi, Tiemei [1 ]
Su, Chang [2 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Ultrasound, Shenyang, Liaoning, Peoples R China
[2] Peoples Hosp Liaoning Prov, Dept Ultrasound, Shenyang, Liaoning, Peoples R China
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2019年 / 45卷 / 03期
关键词：
Ultrasound; Microbubble contrast agents; Deep venous thrombosis; Thrombolysis; Urokinase; VENOUS THROMBOEMBOLISM; IN-VITRO; THROMBOLYTIC THERAPY; RT-PA; DELIVERY;
D O I：
10.1016/j.ultrasmedbio.2018.10.021
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
This study was aimed at assessing the effects of urokinase (UK) in combination with ultrasound and microbubbles in in vitro and in vivo thrombolytic therapy for the treatment of deep vein thrombosis (DVT). Thrombi with formation times of 1, 3, 7, 14 and 21 d were used for thrombolysis. Forty-five adult mongrel dogs were used to evaluate thrombosis in vivo. Both in vitro and in vivo analyses revealed that UK + microbubbles had the best effect among the combinations. Thrombolysis <7 d was more effective at a thrombolysis rate of about 50%, but the thrombolytic effect of thrombi >7 d was poor at thrombolysis rates <30%. Ultrasound + UK significantly increased the thrombolysis rate of thrombi <7 d. These results suggest that the combination of ultrasound with microbubble contrast agents and UK may have a synergistic effect on thrombolysis. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
引用
收藏
页码：859 / 866
页数：8
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