Voltage-Operated Calcium Currents in Retinal Ganglion Cells of the Rat Eye

被引：0
|
作者：
Kuznetsov, K. I. [1 ]
Maslov, V. Yu [1 ,2 ]
Fedulova, S. A. [1 ,2 ]
Veselovsky, N. S. [1 ,2 ]
机构：
[1] Natl Acad Sci Ukraine, Bogomolets Inst Physiol, Kiev, Ukraine
[2] Natl Acad Sci Ukraine, Int Ctr Mol Physiol, Kiev, Ukraine
来源：
NEUROPHYSIOLOGY | 2013年 / 45卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
retinal ganglion cells (RGCs); high- and low-threshold calcium currents; CHANNELS;
D O I：
10.1007/s11062-013-9344-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Using a voltage-clamp technique in the whole-cell configuration, we studied voltage-operated calcium currents in retinal ganglion cells (RGCs) obtained from the rat eye. In all examined cells, we recorded high-threshold calcium currents with the mean maximum amplitude 285 +/- 33 pA (104-593 pA; n = 22) at the membrane potential -10 to 0 mV. In a considerable part of the neurons (10 of 22; 45%), we also observed low-threshold calcium currents (published data on the presence of such currents in mammalian RGCs are contradictory). The mean maximum amplitude of the latter (low-threshold) currents was 99 +/- 11 pA (54-157 pA; n - 10) at the membrane potential -35 mV. The observed differences in the patterns of voltage-dependent calcium currents in various RGCs can be related to functional differentiation of these cells.
引用
收藏
页码：109 / 111
页数：3
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