IDENTIFICATION OF TRANSCRIPTION FACTOR BINDING SITES IN PROMOTER DATABASES

被引：0

作者：

Durast, Ilknur Melis ^{[1
]}

Dag, Ugur ^{[2
]}

Gungor, Burcu Bakzr ^{[1
,3
]}

Erdogan, Burcu ^{[2
]}

Kurnaz, Isil Aksan ^{[2
]}

Sezerman, O. Ugur ^{[1
]}

机构：

[1] Sabanci Univ, Dept Biol Sci & Bioengn, Istanbul, Turkey

[2] Yeditepe Univ, Dept Genet & Bioengn, Istanbul, Turkey

[3] Bahcesehir Univ, Dept Comp Sci & Engn, Istanbul, Turkey

来源：

PROCEEDINGS OF THE 6TH INTERNATIONAL SYMPOSIUM ON HEALTH INFORMATICS AND BIOINFORMATICS (HIBIT'11) | 2011年

关键词：

GENE-REGULATION;

D O I：

暂无

中图分类号：

R-058 [];

学科分类号：

摘要：

Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding motifs. Among ETS family TFs, Pea3 proteins are involved in the regulation of expression of genes, which are important for cell growth, development, differentiation, oncogenic transformation and apoptosis. In silica studies should be done to find out the novel target genes for this TF. Even though a few bioinformatics tools are available for this purpose, the user needs to go back and forth between different tools, and to repeat these steps for each of their candidate gene. Here we combined these tools and constituted a new tool which examines the affinity of any TF towards the selected target genes' promoter sequences. The tool is tested on several genes, which are predicted to be regulated by Pea3 TF.

引用

页码：68 / 73

页数：6

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