Cytotoxic ent-kaurane diterpenoids from isodon rubescens var. rubescens

被引：16
|
作者：
Han, QB
Xiang, W
Li, RT
Li, ML
Li, SW
Sun, HD [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Kunming Med Coll, Yunnan Pharmaceut Lab Nat Prod, Kunming, Peoples R China
来源：
PLANTA MEDICA | 2004年 / 70卷 / 03期
关键词：
D O I：
10.1055/s-2004-818922
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new ent-kauranoids, xindongnins C - G (1 - 5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6 - 10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 mug/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.
引用
收藏
页码：269 / 272
页数：4
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