Lanostane-type triterpenoids from the fruiting bodies of Ganoderma applanatum

被引：26

作者：

Peng, XingRong ^{[1
]}

Li, Lei ^{[1
,2
]}

Dong, JinRun ^{[1
,2
]}

Lu, ShuangYang ^{[1
,2
]}

Lu, Jing ^{[1
,2
]}

Li, XiaoNian ^{[1
]}

Zhou, Lin ^{[1
]}

Qiu, MingHua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

PHYTOCHEMISTRY | 2019年 / 157卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma applanatum (Pers.) Pat; Ganodermataceae; Lanostane-type triterpenoid; X-ray crystallographic analyses; Anti-liver fibrosis activity; LIVER FIBROSIS; TGF-BETA; LUCIDUM; BODY;

D O I：

10.1016/j.phytochem.2018.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve previously undescribed lanostane-type triterpenoids, including three triterpenoids with a gamma-lactone ring, namely applanlactones A-C, four highly oxygenated lanostane triterpenoids, namely methyl applaniate A and applanoic acids B-D, as well as five C21 nortriterpenoids, applanones A-E were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat.. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as X-ray crystallographic analyses. Meanwhile, applanlactone A, methyl applaniate A and applanoic acid B showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro.

引用

页码：103 / 110

页数：8

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