Lanostane-type triterpenoids from the fruiting bodies of Ganoderma applanatum

被引：26
|
作者：
Peng, XingRong [1 ]
Li, Lei [1 ,2 ]
Dong, JinRun [1 ,2 ]
Lu, ShuangYang [1 ,2 ]
Lu, Jing [1 ,2 ]
Li, XiaoNian [1 ]
Zhou, Lin [1 ]
Qiu, MingHua [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Beijing, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
来源：
PHYTOCHEMISTRY | 2019年 / 157卷
基金：
中国国家自然科学基金;
关键词：
Ganoderma applanatum (Pers.) Pat; Ganodermataceae; Lanostane-type triterpenoid; X-ray crystallographic analyses; Anti-liver fibrosis activity; LIVER FIBROSIS; TGF-BETA; LUCIDUM; BODY;
D O I：
10.1016/j.phytochem.2018.10.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Twelve previously undescribed lanostane-type triterpenoids, including three triterpenoids with a gamma-lactone ring, namely applanlactones A-C, four highly oxygenated lanostane triterpenoids, namely methyl applaniate A and applanoic acids B-D, as well as five C21 nortriterpenoids, applanones A-E were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat.. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as X-ray crystallographic analyses. Meanwhile, applanlactone A, methyl applaniate A and applanoic acid B showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro.
引用
收藏
页码：103 / 110
页数：8
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