Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

被引：7

作者：

Narayanarao, Manjunatha ^{[1
]}

Koodlur, Lokesh ^{[2
]}

Revanasiddappa, Vijayakumar G. ^{[3
]}

Gopal, Subramanya ^{[2
]}

Kamila, Susmita ^{[1
]}

机构：

[1] Visvesvaraya Technol Univ, East Point Coll Engn & Technol, Bangalore 560049, Karnataka, India

[2] Vijayanagara Sri Krishnadevaraya Univ, Dept Studies & Res Che, Bellary 583105, India

[3] Tumkur Univ, Univ Coll Sci, Dept Chem, BH Rd, Tumakuru 572103, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷

关键词：

L-proline; ninhydrin; sarcosine; spiropyrrolidine; 5-vinylindazole; 5-vinylindole; ONE-POT SYNTHESIS; 3-COMPONENT; DERIVATIVES; INHIBITORS;

D O I：

10.3762/bjoc.12.288

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis. The method uses the 1,3-dipolar cycloaddition reaction between N-alkylvinylindole/indazole and azomethine ylides, prepared in situ from cyclic/acyclic amino acids. The 1,3-dipolar cycloaddition proceeds efficiently under thermal conditions to afford the regio- and stereospecific cyclic adducts.

引用

页码：2893 / 2897

页数：5

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