Serum Alpha-Fetoprotein Predicts Treatment Outcome in Chronic Hepatitis C Patients Regardless of HCV Genotype

被引：15
|
作者：
Abdoul, Hendy [1 ]
Mallet, Vincent [2 ]
Pol, Stanislas [2 ]
Fontanet, Arnaud [1 ]
机构：
[1] Inst Pasteur, Unite Epidemiol Malad Emergentes, Paris, France
[2] Univ Paris 05, Hop Cochin, APHP, Unite Hepatol, INSERM U567, Paris, France
来源：
PLOS ONE | 2008年 / 3卷 / 06期
关键词：
D O I：
10.1371/journal.pone.0002391
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We examined the association between serum alpha-fetoprotein (AFP) level and sustained virological response (SVR) in 93 chronic hepatitis C patients. The SVR rate was much higher among patients with serum AFP levels below rather than above the median value (5.7 ng/ml) (58.7% and 19.2%, respectively; P < 0.0001). Serum AFP should be added to the list of factors predictive of treatment response in chronic hepatitis C.
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页数：4
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