Surprising Differences in the Variability of Y Chromosomes in African and Cosmopolitan Populations of Drosophila melanogaster

被引:25
|
作者
Larracuente, Amanda M. [1 ,2 ]
Clark, Andrew G. [1 ]
机构
[1] Cornell Univ, Ithaca, NY 14853 USA
[2] Univ Rochester, Dept Biol, Rochester, NY 14627 USA
基金
美国国家卫生研究院;
关键词
RATIO MEIOTIC DRIVE; GENE-EXPRESSION; NATURAL-POPULATIONS; NUCLEOTIDE POLYMORPHISM; EUROPEAN POPULATIONS; RECOMBINATION EVENTS; HISTORY; SELECTION; PATTERNS; NUMBER;
D O I
10.1534/genetics.112.146167
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The nonrecombining Drosophila melanogaster Y chromosome is heterochromatic and has few genes. Despite these limitations, there remains ample opportunity for natural selection to act on the genes that are vital for male fertility and on Y factors that modulate gene expression elsewhere in the genome. Y chromosomes of many organisms have low levels of nucleotide variability, but a formal survey of D. melanogaster Y chromosome variation had yet to be performed. Here we surveyed Y-linked variation in six populations of D. melanogaster spread across the globe. We find surprisingly low levels of variability in African relative to Cosmopolitan (i.e., non-African) populations. While the low levels of Cosmopolitan Y chromosome polymorphism can be explained by the demographic histories of these populations, the staggeringly low polymorphism of African Y chromosomes cannot be explained by demographic history. An explanation that is entirely consistent with the data is that the Y chromosomes of Zimbabwe and Uganda populations have experienced recent selective sweeps. Interestingly, the Zimbabwe and Uganda Y chromosomes differ: in Zimbabwe, a European Y chromosome appears to have swept through the population.
引用
收藏
页码:201 / 214
页数:14
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