THE CYP2D6 'ENHANCER' SNP: LONG-RANGE LINKAGE ANALYSIS AND IMPACT ON ACTIVITY IN HUMAN LIVER TISSUE

被引:0
|
作者
Gaedigk, Andrea [1 ]
Boone, Erin C. [1 ]
Dinh, Jean C. [1 ]
Gaedigk, Roger [1 ]
Lata, Ryan F. [1 ]
Pearce, Robin E. [1 ]
Wang, Wendy Y. [1 ]
Miller, Neil A. [1 ]
Staggs, Vincent S. [1 ]
Leeder, J. Steven [1 ]
机构
[1] Childrens Mercy Kansas City, Kansas City, MO USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
P191
引用
收藏
页码:S80 / S81
页数:3
相关论文
共 50 条
  • [31] CYP2D6 Protein Level Is the Major Contributor to Interindividual Variability in CYP2D6-Mediated Drug Metabolism in Healthy Human Liver Tissue
    Ning, Miaoran
    Duarte, Julio D.
    Rubin, Leah H.
    Jeong, Hyunyoung
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 104 (05) : 974 - 982
  • [32] Immunohistochemical assessment of CYP2D6 expression in normal human tissue.
    Zanger, UM
    Fritz, P
    Behrle, E
    Friedel, A
    Kivisto, K
    Eichelbaum, M
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 355 (04) : 456 - 456
  • [33] CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver
    Dehal, SS
    Kupfer, D
    CANCER RESEARCH, 1997, 57 (16) : 3402 - 3406
  • [34] Timolol metabolism in human liver microsomes is mediated principally by CYP2D6
    Volotinen, Marjo
    Turpeinen, Miia
    Tolonen, Ari
    Uusitalo, Jouko
    Maenpaa, Jukka
    Pelkonen, Olavi
    DRUG METABOLISM AND DISPOSITION, 2007, 35 (07) : 1135 - 1141
  • [35] Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes
    He, Nu
    Xie, Hong-Guang
    Collins, Xavier
    Edeki, Timi
    Yan, Zhengyin
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2006, 33 (09): : 813 - 815
  • [36] Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity
    Doki, Kosuke
    Sekiguchi, Yukio
    Kuga, Keisuke
    Aonuma, Kazutaka
    Homma, Masato
    DRUG METABOLISM AND PHARMACOKINETICS, 2015, 30 (04) : 257 - 262
  • [37] CYP2D6 expression is regulated by polymorphisms that affect splicing and trancription: new biomarkers for CYP2D6 activity
    Wang, Danxin
    Poi, Ming J.
    Sun, Xiaochun
    Gaedigk, Andrea
    Leeder, J. Steven
    Sadee, Wolfgang
    FASEB JOURNAL, 2013, 27
  • [38] Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population
    Ishiguro, A
    Kubota, T
    Sasaki, H
    Yamada, Y
    Iga, T
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 55 (04) : 414 - U3
  • [39] A novel CYP2D6 scoring system for the prediction of CYP2D6 activity: Application to tamoxifen metabolism.
    Borges, S.
    Li, L.
    Robarge, J.
    Nguyen, A.
    Azzouz, F.
    Desta, Z.
    Skaar, T.
    Flockhart, D. A.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 : S67 - S67
  • [40] Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice
    Tolledo, Cole
    Stocco, Marlaina R.
    Miksys, Sharon
    Gonzalez, Frank J.
    Tyndale, Rachel F.
    MOLECULAR NEUROBIOLOGY, 2020, 57 (06) : 2509 - 2520