Host-pathogen interaction in HIV infection

被引：9
|
作者：
Chowdhury, Ankita [1 ]
Silvestri, Guido
机构：
[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 04期
关键词：
SIMIAN IMMUNODEFICIENCY VIRUS; T FOLLICULAR HELPER; IMMUNE ACTIVATION; LYMPHOID-TISSUE; SIV INFECTION; NEUTRALIZING ANTIBODIES; ANTIRETROVIRAL THERAPY; CELL HOMEOSTASIS; CHIMERIC VIRUS; SOOTY MANGABEY;
D O I：
10.1016/j.coi.2013.07.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The host-pathogen interaction is strikingly complex during HIV infection. While several immune effector mechanisms (i.e. cytotoxic T cells, neutralizing antibodies, NK cells, among others) can play a strong antiviral role in vivo, the virus is remarkably able to evade these responses. In addition, the virus preferentially infects and kills activated memory CD4+ T cells, thus exploiting the host antiviral immune response as a source of new cellular targets for infection. Recent advances in understanding (i) how HIV perturbs the host immune system, (ii) how the immune system fights HIV; and (iii) how HIV disease persists when virus replication is suppressed by antiretroviral drugs may hopefully lead to better prevention and treatment strategies for this deadly viral infection.
引用
收藏
页码：463 / 469
页数：7
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