Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival

被引：6
|
作者：
de Foubert, Georgina [1 ]
Khundakar, Ahmad A. [2 ]
Zetterstroem, Tyra S. [1 ]
机构：
[1] De Montfort Univ, Fac Hlth & Life Sci, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England
[2] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
来源：
NEUROSCIENCE LETTERS | 2013年 / 553卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
Brain derived neurotrophic factor; BDNF; 5-HT6; receptors; Neurogenesis; Serotonin; Antidepressant drugs; ANTIDEPRESSANT DRUG-TREATMENT; NEUROTROPHIC FACTOR; RAT-BRAIN; ELECTROCONVULSIVE SHOCK; MESSENGER-RNA; HIPPOCAMPUS; DEPRESSION; NEUROGENESIS; PROTEIN; PROLIFERATION;
D O I：
10.1016/j.neulet.2013.08.029
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：211 / 215
页数：5
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