Lewis acid-catalyzed Csp3-H functionalization of methyl azaarenes with α-trifluoromethyl carbonyl compounds

被引：59
|
作者：
Graves, Vincent B. [1 ]
Shaikh, Abid [1 ]
机构：
[1] Georgia So Univ, Dept Chem, Statesboro, GA 30460 USA
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 07期
关键词：
Azaarenes; C-H functionalization; Trifluoromethyl ketone; Catalysis; Lewis acid; C-H BOND; N-SULFONYL ALDIMINES; SITE-SELECTIVE SP(2); DIRECT ARYLATION; OLEFINATION;
D O I：
10.1016/j.tetlet.2012.12.013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Lewis acid promoted Csp(3)-H bond functionalization of methyl azaarenes with alpha-trifluoromethylated carbonyl compounds is described. Catalytic amounts of Yb(OTf)(3) provided a straightforward access to the corresponding trifluoromethylated alcohols in excellent yields up to 94% under mild reaction conditions. Published by Elsevier Ltd.
引用
收藏
页码：695 / 698
页数：4
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