Kinase cogs go forward and reverse in the Wnt signaling machine

被引：10

作者：

Dale, T ^{[1
]}

机构：

[1] Cardiff Sch Biosci, Cardiff CF10 3US, Wales

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 01期

关键词：

D O I：

10.1038/nsmb0106-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An important link between Wnt binding at the cell surface and nuclear β-catenin–TCF–dependent transcription has been made with the identification of kinases that promote the association of the Wnt receptor and β-catenin turnover complexes. Surprisingly, the enzymes implicated had previously been suggested to inhibit rather than promote Wnt signaling.

引用

页码：9 / 11

页数：4

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