Kinase cogs go forward and reverse in the Wnt signaling machine

被引：10
|
作者：
Dale, T [1 ]
机构：
[1] Cardiff Sch Biosci, Cardiff CF10 3US, Wales
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 01期
关键词：
D O I：
10.1038/nsmb0106-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An important link between Wnt binding at the cell surface and nuclear β-catenin–TCF–dependent transcription has been made with the identification of kinases that promote the association of the Wnt receptor and β-catenin turnover complexes. Surprisingly, the enzymes implicated had previously been suggested to inhibit rather than promote Wnt signaling.
引用
收藏
页码：9 / 11
页数：4
相关论文
共 50 条
12345