The value of virtual touch tissue imaging quantification combined with color Doppler ultrasound and CA153 in diagnosing early breast cancer

Objective: To explore the value of virtual touch tissue imaging quantification combined with color Doppler ultrasound and carbohydrate antigen 153 (CA153) in diagnosis of early breast cancer. Methods: Clinical data of 196 patients with breast masses were collected and analyzed proactively. Among these patients, 89 patients were confirmed with malignant breast tumor and 107 patients were confirmed with benign breast tumor according to final pathological report. The breast imaging reporting and data system (BI-RADS) grading quantitative score, transverse shear wave velocity (SWV), and CA153 level of all patients were analyzed. Results: The BI-RADS grading quantitative score, SWV, and CA153 level of the malignant tumor group were all significantly higher than those of the benign tumor group (all P<0.05). The area under the receiver operating characteristic curve (AUC) of SWV in diagnosing breast cancer was 0.855, and when SWV was 4.205 m/s, its sensitivity and specificity were 0.640 and 0.981, respectively; The AUC of BI-RADS score in diagnosing breast cancer was 0.797, and when the BI-RADS grading quantitative score was 3.5 points, its sensitivity and specificity were 0.798 and 0.636, respectively. The AUC of CA153 in diagnosing breast cancer was 0.838, and when the CA153 level was 19.99 U/mL, its sensitivity and specificity were 0.663 and 0.981, respectively. In addition, the AUC of SWV combined with BI-RADS grading quantitative score and CA153 in diagnosing breast cancer was 0.978, and its sensitivity and specificity were 0.910 and 0.953, respectively. Conclusion: Virtual touch tissue imaging quantification combined with color Doppler ultrasound and CA153 is of a high value in the diagnosis of breast cancer, so it is worthy of clinical application.