Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders

被引:88
|
作者
Gilbert, Jack A. [1 ,2 ]
Krajmalnik-Brown, Rosa [3 ,4 ]
Porazinska, Dorota L. [5 ,6 ]
Weiss, Sophie J. [5 ,6 ]
Knight, Rob [5 ,6 ,7 ]
机构
[1] Argonne Natl Lab, Inst Genom & Syst Biol, Argonne, IL 60439 USA
[2] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA
[3] Arizona State Univ, Swette Ctr Environm Biotechnol, Biodesign Inst, Tempe, AZ 85287 USA
[4] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA
[5] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
[6] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA
[7] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA
关键词
GUT MICROBIOTA;
D O I
10.1016/j.cell.2013.11.035
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.
引用
收藏
页码:1446 / 1448
页数:3
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