Elevated Microparticles, Thrombin-antithrombin and VEGF Levels in Colorectal Cancer Patients Undergoing Chemotherapy

被引:13
|
作者
Wojtukiewicz, Marek Z. [1 ]
Mysliwiec, Marta [1 ]
Sierko, Ewa [1 ,2 ]
Sobierska, Monika [1 ,3 ]
Kruszewska, Joanna [1 ]
Lipska, Alina [3 ]
Radziwon, Piotr [3 ,4 ]
Tucker, Stephanie C. [5 ,6 ]
Honn, Kenneth, V [5 ,7 ,8 ]
机构
[1] Med Univ Bialystok, Dept Oncol, 12 Ogrodowa St, PL-15027 Bialystok, Poland
[2] Comprehens Canc Ctr, Dept Radiotherapy, Bialystok, Poland
[3] Reg Ctr Transfus Med, Bialystok, Poland
[4] Med Univ Bialystok, Dept Hematol, Bialystok, Poland
[5] Wayne State Univ, Dept Pathol, Bioact Lipids Res Program, Sch Med, Detroit, MI 48202 USA
[6] Karmanos Canc Inst, Detroit, MI 48201 USA
[7] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA
[8] Wayne State Univ, Dept Oncol, Detroit, MI 48202 USA
关键词
Endothelium-derived microparticles; Blood coagulation; Angiogenesis; Colorectal cancer; ENDOTHELIAL GROWTH-FACTOR; FACTOR-POSITIVE MICROPARTICLES; TISSUE FACTOR ACTIVITY; VENOUS THROMBOEMBOLISM; HEMOSTATIC SYSTEM; EXTRACELLULAR VESICLES; TUMOR ANGIOGENESIS; PROGNOSTIC VALUE; ACTIVATION; EXPRESSION;
D O I
10.1007/s12253-020-00854-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hypercoagulable state and neoangiogenesis are common phenomena associated with malignancy. Cancer patients have increased levels of circulating endothelium-derived microparticles (EMPs), which have been hypothesized to be involved in numerous pathophysiological processes. Hemostasis and angiogenesis are also activated in colorectal cancer (CRC) patients. The study aimed to investigate potential influence of chemotherapy on EMPs, thrombin anti-thrombin complex (TAT) and vascular endothelial growth factor (VEGF) levels in CRC patients undergoing chemotherapy. The study group consisted of 18 CRC patients: 8 stage III colon cancer (CC) and 10 stage IV rectal cancer (RC) patients. EMPs, TAT and VEGF levels were assessed before chemotherapy and after the third course. Results were compared with 10 healthy subjects. EMP concentration was measured by flow cytometry, while TAT and VEGF concentrations were assayed employing ELISA. Compared to the control group, CC and RC patients had significantly higher levels of tissue factor (TF)-bearing and non-TF-bearing EMPs before and after three courses of chemotherapy. VEGF concentrations in CRC patients were higher than in the control groups and increased following chemotherapy. TAT levels were elevated in CRC patients before chemotherapy compared to healthy subjects and significantly increased after the third course of chemotherapy. No significant correlation was found either between EMP and TAT levels, or between EMP concentrations and VEGF levels in the study group. CRC patients have increased EMPs, and TAT as well as VEGF levels tend to increase during chemotherapy.
引用
收藏
页码:2499 / 2507
页数:9
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