Synthesis of 7-alkyl-4-amino-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acids

被引：1

作者：

Verves, E. V. ^{[1
]}

Kucher, A. V. ^{[1
]}

Muzychka, L. V. ^{[1
]}

Smolii, O. B. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 48卷 / 12期

关键词：

ethyl N-alkylglycinate; pyrimido[5 ',4 ':4,5]pyrrolo[2,1-c][1,4]oxazine; 7H-pyrrolo[2,3-d]pyrimidine; cyclization;

D O I：

10.1007/s10593-013-1218-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two variants are discussed for the synthesis of ethyl N-alkyl-N-(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimido- [5',4':4,5]pyrrolo[2,1-c][1,4]oxazines containing 3-chloropropyl groups at position 8 have been prepared.

引用

页码：1844 / 1852

页数：9

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