Synthesis of New Thienopyridine Derivatives by [3+2]- and [2+2]-Cycloaddition Reactions

被引：7

作者：

Milen, Matyas ^{[1
,2
]}

Abranyi-Balogh, Peter ^{[1
]}

Dancso, Andras ^{[2
]}

Keglevich, Gyoergy ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

[2] EGIS Pharmaceut PLC, Div Chem Res, H-1475 Budapest, Hungary

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 22期

关键词：

heterocycles; cycloadditions; nitrile oxides; nitrile imines; Staudinger reactions; NITRILE OXIDES; CYCLOADDITION REACTIONS; CLOPIDOGREL; NITRILIMINES; 3,4-DIHYDRO-BETA-CARBOLINES; 1,3-DIPOLES; TICLOPIDINE; STAUDINGER; PRECURSORS; REACTIVITY;

D O I：

10.1055/s-0032-1316794

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 6,7-dihydrothieno[3,2-c]pyridine derivatives with 1,3-dipoles, such as a nitrile oxides or nitrile imines, gave novel fused heterocycles. The Staudinger reaction of the starting material was also studied. This reaction was stereoselective and exclusively gave racemic cis-cycloadducts in which the thienopyridine core was fused with a beta-lactam ring.

引用

页码：3447 / 3452

页数：6

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