Rapid analytical method development using multiparallel microfluidic high-performance liquid chromatography in support of pharmaceutical process research

被引：8
|
作者：
Sajonz, Peter [1 ]
Schafer, Wes [1 ]
Leonard, William R. [1 ]
Gong, Xiaoyi [1 ]
Shultz, Scott [1 ]
Rosner, Thorsten [1 ]
Sun, Yongkui [1 ]
Welch, Christopher J. [1 ]
机构：
[1] Merck & Co Inc, Separat & Anal Technol, Rahway, NJ 07065 USA
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2008年 / 31卷 / 15期
关键词：
asymmetric hydrogenation; catalyst screening; chromatography; high throughput; HPLC; microfluidic; multiparallel; normal phase;
D O I：
10.1080/10826070802281653
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Rapid chiral method development using microfluidic multiparallel HPLC is illustrated with several examples of 'real world' pharmaceutical intermediates for which speed was critical for successful process development. It is shown that this rapid chiral method development approach is suitable for support of high throughput screening of enantioselective catalytic hydrogenation reactions and other high throughput experimentation initiatives in pharmaceutical process research.
引用
收藏
页码：2296 / 2304
页数：9
相关论文
共 50 条
  • [41] Analytical Method Development for Bisphenol A in Tuna by using High Performance Liquid Chromatography-UV
    Aristiawan, Yosi
    Aryana, Nurhani
    Putri, Dillani
    Styarini, Dyah
    INTERNATIONAL SYMPOSIUM ON APPLIED CHEMISTRY 2015, 2015, 16 : 202 - 208
  • [42] A RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF MELAMINE IN RENAL CALCULI
    Chang, Hong
    Shi, Xiaofeng
    Zhang, Fanghong
    Sheng, Wei
    Wang, Dongdong
    Yue, Zhongjin
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2012, 35 (1-4) : 258 - 267
  • [43] A RAPID METHOD FOR THE DETERMINATION OF PIROXICAM IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    MAYA, MT
    PAIS, JP
    MORAIS, JA
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (03) : 319 - 322
  • [44] RAPID METHOD FOR THE DETERMINATION OF UROKINASE ACTIVITY BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    SOMENO, T
    KATOH, K
    NIIJIMA, K
    MIYAZAKI, H
    JOURNAL OF CHROMATOGRAPHY, 1980, 188 (01): : 185 - 192
  • [45] A RAPID, ISOCRATIC METHOD FOR PHOSPHOLIPID SEPARATION BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    KADUCE, TL
    NORTON, KC
    SPECTOR, AA
    JOURNAL OF LIPID RESEARCH, 1983, 24 (10) : 1398 - 1403
  • [46] RAPID METHOD FOR DETERMINATION OF RIBOFLAVIN IN URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    SMITH, MD
    JOURNAL OF CHROMATOGRAPHY, 1980, 182 (3-4): : 285 - 291
  • [47] A RAPID METHOD FOR THE DETERMINATION OF METHOPRENE IN TOBACCO BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    YANG, SS
    CHROMATOGRAPHIA, 1992, 33 (7-8) : 309 - 312
  • [48] Rapid method for the analysis of itraconazole and hydroxyitraconazole in serum by high-performance liquid chromatography
    Compas, D
    Touw, DJ
    deGoede, PNFC
    JOURNAL OF CHROMATOGRAPHY B, 1996, 687 (02): : 453 - 456
  • [49] A METHOD FOR RAPID-DETERMINATION OF LORAZEPAM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    KONDO, T
    BUSS, DC
    ROUTLEDGE, PA
    THERAPEUTIC DRUG MONITORING, 1993, 15 (01) : 35 - 38
  • [50] Rapid high-performance liquid chromatography method for determination of tryptophan in gastric juice
    Lian, Wei
    Ma, Dong Jie
    Xu, Xu
    Chen, Ying
    Wu, Yun Lin
    JOURNAL OF DIGESTIVE DISEASES, 2012, 13 (02) : 100 - 106
12345