Rapid analytical method development using multiparallel microfluidic high-performance liquid chromatography in support of pharmaceutical process research

被引：8
|
作者：
Sajonz, Peter [1 ]
Schafer, Wes [1 ]
Leonard, William R. [1 ]
Gong, Xiaoyi [1 ]
Shultz, Scott [1 ]
Rosner, Thorsten [1 ]
Sun, Yongkui [1 ]
Welch, Christopher J. [1 ]
机构：
[1] Merck & Co Inc, Separat & Anal Technol, Rahway, NJ 07065 USA
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2008年 / 31卷 / 15期
关键词：
asymmetric hydrogenation; catalyst screening; chromatography; high throughput; HPLC; microfluidic; multiparallel; normal phase;
D O I：
10.1080/10826070802281653
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Rapid chiral method development using microfluidic multiparallel HPLC is illustrated with several examples of 'real world' pharmaceutical intermediates for which speed was critical for successful process development. It is shown that this rapid chiral method development approach is suitable for support of high throughput screening of enantioselective catalytic hydrogenation reactions and other high throughput experimentation initiatives in pharmaceutical process research.
引用
收藏
页码：2296 / 2304
页数：9
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