Homoisoflavanones with estrogenic activity from the rhizomes of Polygonatum sibiricum

被引：22

作者：

Chen, Hui ^{[1
,2
]}

Li, Yu-Jie ^{[3
]}

Li, Xiao-Fei ^{[1
]}

Sun, Yan-Jun ^{[1
,2
]}

Li, Hong-Wei ^{[1
,2
]}

Su, Fang-Yi ^{[1
,2
]}

Cao, Yan-Gang ^{[1
]}

Zhang, Yan-Li ^{[1
,2
]}

Zheng, Xiao-Ke ^{[1
,2
]}

Feng, Wei-Sheng ^{[1
,2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China

[2] Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengzhou 450046, Henan, Peoples R China

[3] Henan Univ Chinese Med, Sch Basic Med, Zhengzhou 450046, Henan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 01期

关键词：

Liliaceae; Polygonatum sibiricum; homoisoflavanones; estrogenic activity; molecular docking; HOMOISOFLAVONOIDS; CONSTITUENTS; ODORATUM; RECEPTORS;

D O I：

10.1080/10286020.2017.1343821

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new homoisoflavanone, (3R)-5-hydroxy-7-methoxyl-3-(2'-hydroxy-4'- methoxybenzyl)-chroman-4-one (1), together with six known analogs, were isolated from the rhizomes of Polygonatum sibiricum. Their structures were elucidated on the basis of extensive spectroscopic analysis. All compounds were tested for their estrogenic activity using the MCF-7 estrogenresponsive human breast cancer cell lines. At a dose of 0.1 mu mol/L, compounds 1-7 exhibited significant proliferative effects on MCF-7 cells compared with E-2. The molecular docking study results indicated that the activity of compounds 3, 5, 6, and 7 may be the binding with ERR. GRAPHICS

引用

页码：92 / 100

页数：9

共 50 条

[11] Effect of steaming process on the structural characteristics and antioxidant activities of polysaccharides from Polygonatum sibiricum rhizomes
Li, Qinying
Zeng, Jun
Gong, Pixian
Wu, Yanchao
Li, Huijing
GLYCOCONJUGATE JOURNAL, 2021, 38 (05) : 561 - 572
[12] Gas chromatographic determination of azetidine-2-carboxylic acid in rhizomes of Polygonatum sibiricum and Polygonatum odoratum
Baek, Seung-Hoon
Lee, Jin Gyun
Park, Seo Young
Piao, Xiang-Lan
Kim, Hyun Young
Bae, Ok-Nam
Park, Jeong Hill
JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2012, 25 (02) : 137 - 141
[13] Effect of steaming process on the structural characteristics and antioxidant activities of polysaccharides from Polygonatum sibiricum rhizomes
Qinying Li
Jun Zeng
Pixian Gong
Yanchao Wu
Huijing Li
Glycoconjugate Journal, 2021, 38 : 561 - 572
[14] Cardiotonic activity of the Rhizome of Polygonatum sibiricum in rats
Hirai, N
Miura, T
Moriyasu, M
Ichimaru, M
Nishiyama, Y
Ogura, K
Kato, A
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1997, 20 (12) : 1271 - 1273
[15] Comparative Study of the Phytochemical Profiles of the Rhizomes of Cultivated and Wild-Grown Polygonatum sibiricum
Pan, Zhibin
Cheng, Weiqing
Liu, Zhibin
Wu, Weibin
Yang, Bin
Lin, Junhan
SEPARATIONS, 2022, 9 (12)
[16] Chemical constituents from the rhizomes of Polygonatum sibiricum Red. and anti-inflammatory activity in RAW264.7 macrophage cells
Zhao, Huan
Wang, Qiao-Lian
Hou, Shu-Bing
Chen, Guang
NATURAL PRODUCT RESEARCH, 2019, 33 (16) : 2359 - 2362
[17] Two New Homoisoflavanones from the Rhizome of Polygonatum odoratum
Yan-Yun Che
Yong Qian
Yi Wu
Jing-Yu Wei-Qu
Chemistry of Natural Compounds, 2015, 51 : 54 - 56
[18] Chemical constituents with antisepsis activity from the rhizomes of Polygonatum odoratum
Dong-Mei Wang
Deng-Wu Li
Wei Zhu
Pai Peng
Chemistry of Natural Compounds, 2009, 45 : 876 - 880
[19] CHEMICAL CONSTITUENTS WITH ANTISEPSIS ACTIVITY FROM THE RHIZOMES OF Polygonatum odoratum
Wang, Dong-Mei
Li, Deng-Wu
Zhu, Wei
Peng, Pai
CHEMISTRY OF NATURAL COMPOUNDS, 2009, 45 (06) : 876 - 880
[20] Structural characterization and antioxidant activity of Polygonatum sibiricum polysaccharides
Wang, Shiqiang
Li, Gang
Zhang, Xinfei
Wang, Yuqian
Qiang, Yi
Wang, Bulei
Zou, Jiabin
Niu, Junfeng
Wang, Zhezhi
Carbohydrate Polymers, 2022, 291

← 1 2 3 4 5 →