Therapeutic prospects for p73 and p63: Rising from the shadow of p53

被引：49
|
作者：
Vilgelm, Anna [1 ,2 ]
El-Rifai, Wael [1 ,3 ,4 ]
Zaika, Alexander [1 ,3 ,4 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Dept Surg, Nashville, TN 37232 USA
[2] Russian Acad Sci, Inst Mol Biol, Dept Cell Biol, Moscow, Russia
[3] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA
[4] Vanderbilt Ingram Canc Ctr, Nashville, TN USA
来源：
DRUG RESISTANCE UPDATES | 2008年 / 11卷 / 4-5期
关键词：
Apoptosis; E2F1; ZEB1; RETRA; iASPP; YAP1; Drug resistance;
D O I：
10.1016/j.drup.2008.08.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The p53 protein family consists of three transcription factors: p53, p63, and p73. These proteins share significant structural and functional similarities and each has unique biological functions as well. Although the role of p53 in cellular stress is extensively studied, many questions remain about p63 and p73. In this review we summarize current data on functional interactions within the p53 family, their regulation and roles in response to genotoxic stress. We also discuss the significance of p73 and p63 for cancer therapy and outline novel approaches in development of therapeutic drugs that specifically target the p53 family. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：152 / 163
页数：12
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