Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction

被引：3
|
作者：
Franco-Molina, Moises A. [1 ]
Mendoza-Gamboa, Edgar [1 ]
Coronado-Cerda, Erika E. [1 ]
Zarate-Trivino, Diana [1 ]
Arizpe-Coronado, Juan E. [2 ]
Zapata-Benavides, Pablo [1 ]
Ramos Zayas, Yareellys [1 ]
Tamez-Guerra, Reyes [1 ]
Rodriguez-Padilla, Cristina [1 ]
机构：
[1] Autonomous Univ Nuevo Leon, Fac Biol Sci, Dept Microbiol & Immunol, San Nicolas De Los Garza, Mexico
[2] Autonomous Univ Nuevo Leon, Fac Odontol, Dept Oral & Maxillofacial Surg, San Nicolas De Los Garza, Mexico
来源：
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | 2017年 / 31卷 / 01期
关键词：
Surgery; saliva; inflammation; cytokine; IMMUNEPOTENT CRP; SURGICAL EXTRACTION; DOUBLE-BLIND; EFFICACY; PAIN; COMBINATION; THERAPY; SURGERY; TRISMUS; LEVEL;
D O I：
10.1080/13102818.2016.1249408
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin and Laskin, and the analysis of cytokine production (IL-2, IL-4, IL-6, IL-10, TNF-alpha, INF-gamma) in saliva was done by flow cytometry. The swelling process after surgery was significant (p < 0.05) and the treatments with IMMUNEPOTENT CRP or ibuprofen controlled this process properly; no difference between the groups was found (p < 0.05). Both treatments were shown to modulate the cytokine production. These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice.
引用
收藏
页码：182 / 186
页数：5
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