Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

被引：27

作者：

Sharma, Ashok ^{[1
,2
]}

Valle, Maria L. ^{[1
]}

Beveridge, Connor ^{[1
]}

Liu, Yutao ^{[1
,3
]}

Sharma, Shruti ^{[1
,4
]}

机构：

[1] Augusta Univ, Ctr Biotechnol & Genom Med, Med Coll Georgia, Augusta, GA 30912 USA

[2] Augusta Univ, Med Coll Georgia, Dept Populat Hlth Sci, Augusta, GA 30912 USA

[3] Augusta Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA

[4] Augusta Univ, Med Coll Georgia, Dept Ophthalmol, Augusta, GA 30912 USA

来源：

EYE | 2019年 / 33卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; CHINESE PATIENTS; PROLIFERATIVE RETINOPATHY; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULE-1; GROWTH-FACTOR; INSULIN; POLYMORPHISMS; METAANALYSIS; VARIANT;

D O I：

10.1038/s41433-019-0337-y

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

引用

页码：534 / 541

页数：8

共 50 条

[21] Genetics of Diabetic Retinopathy
Han, Jonathan
Lando, Leonardo
Skowronska-Krawczyk, Dorota
Chao, Daniel L.
CURRENT DIABETES REPORTS, 2019, 19 (09)
[22] Genetics of Diabetic Retinopathy
Cho, Heeyoon
Sobrin, Lucia
CURRENT DIABETES REPORTS, 2014, 14 (08)
[23] The role lipid aldehydes and ALEs in the pathogenesis of diabetic retinopathy
Curtis, Tim
FREE RADICAL BIOLOGY AND MEDICINE, 2014, 75 : S8 - S8
[24] Role of interleukin-1β in the pathogenesis of diabetic retinopathy
Kowluru, RA
Odenbach, S
BRITISH JOURNAL OF OPHTHALMOLOGY, 2004, 88 (10) : 1343 - 1347
[25] The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy
Tomic, Martina
Ljubic, Spomenka
Kastelan, Snjezana
COLLEGIUM ANTROPOLOGICUM, 2013, 37 : 51 - 57
[26] Role of perfusion pressure in the pathogenesis and severity of diabetic retinopathy
Panzan, CQ
Verma, D
Yanai, D
Rossi, JV
Fujii, GY
Dave, D
Walton, C
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U414 - U414
[27] The role of GLUT1 in the pathogenesis of Diabetic Retinopathy
Calado, S. M.
Alves, L. S.
Simao, S.
Bitoque, D. B.
Silva, G. A.
HUMAN GENE THERAPY, 2015, 26 (10) : A82 - A83
[28] Role of Cytokines and Trophic Factors in the Pathogenesis of Diabetic Retinopathy
Mitamura, Yoshinori
Harada, Chikako
Harada, Takayuki
CURRENT DIABETES REVIEWS, 2005, 1 (01) : 73 - 81
[29] The role of IGF-I in the pathogenesis of diabetic retinopathy
Poulaki, V
Joussen, AM
Mitsiades, N
Adamis, AP
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U837 - U837
[30] The pathogenesis of diabetic retinopathy
Stanford, MR
BRITISH JOURNAL OF OPHTHALMOLOGY, 2004, 88 (04) : 444 - 445

← 1 2 3 4 5 →