Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

被引：27
|
作者：
Sharma, Ashok [1 ,2 ]
Valle, Maria L. [1 ]
Beveridge, Connor [1 ]
Liu, Yutao [1 ,3 ]
Sharma, Shruti [1 ,4 ]
机构：
[1] Augusta Univ, Ctr Biotechnol & Genom Med, Med Coll Georgia, Augusta, GA 30912 USA
[2] Augusta Univ, Med Coll Georgia, Dept Populat Hlth Sci, Augusta, GA 30912 USA
[3] Augusta Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA
[4] Augusta Univ, Med Coll Georgia, Dept Ophthalmol, Augusta, GA 30912 USA
来源：
EYE | 2019年 / 33卷 / 04期
关键词：
GENOME-WIDE ASSOCIATION; CHINESE PATIENTS; PROLIFERATIVE RETINOPATHY; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULE-1; GROWTH-FACTOR; INSULIN; POLYMORPHISMS; METAANALYSIS; VARIANT;
D O I：
10.1038/s41433-019-0337-y
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.
引用
收藏
页码：534 / 541
页数：8
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