Synthesis of the ω-brominated α-trifluoroacetylcycloalkanones and their isoxazole derivatives

被引：11

作者：

Flores, AFC ^{[1
]}

Peres, RL ^{[1
]}

Piovesan, LA ^{[1
]}

Flores, DC ^{[1
]}

Bonacorso, HG ^{[1
]}

Martins, MAP ^{[1
]}

机构：

[1] Univ Fed Santa Maria, NUQUIMHE, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2006年 / 17卷 / 01期

关键词：

omega-bromo-alpha-trifluoroacetylcycloalkanones; 2-trifluoroacetylcycloalkanones; bromination reactions; cyclocondensation; isoxazoles;

D O I：

10.1590/S0103-50532006000100012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactions of a serie of the 2-trifluoroacetyl-1-methoxy-1-cycloalkenes (1a-1e) and 2-trifluoroacetylcycloalkanones (2a-2e) with molecular bromine to obtain omega-bromo-atrifluoroacetylcycloalkanones (3a-3e, 4a) is reported. Was determined that 2-trifluoroacetyl group have established the C-omega as reactive site. The 2-trifluoroacetylcycloalkanones and omega-bromo-alpha-trifluoroacetylcycloalkanones were reacted with hydroxylamine hydrochloride leading to respective 5-trifluoromethyl-5-hydroxy-4,5-dihydro-3,4-polimethyleneisoxazole derivatives (5c-5e and 6c-6e).

引用

页码：79 / 84

页数：6

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