The role of microRNAs in metal carcinogen-induced cell malignant transformation and tumorigenesis

被引：30
|
作者：
Humphries, Brock [1 ,2 ]
Wang, Zhishan [1 ]
Yang, Chengfeng [1 ,2 ,3 ]
机构：
[1] Michigan State Univ, Dept Physiol, 2201 Biomed Phys Sci, E Lansing, MI 48824 USA
[2] Michigan State Univ, Cellular & Mol Biol Grad Program, E Lansing, MI 48824 USA
[3] Michigan State Univ, Inst Integrat Toxicol, E Lansing, MI 48824 USA
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2016年 / 98卷
基金：
美国国家卫生研究院;
关键词：
MicroRNA (miRNA); Epigenetics; Metal; Metal carcinogenesis; Arsenic; Cadmium; Chromium; Nickel; BRONCHIAL EPITHELIAL-CELLS; KINASE-C-ALPHA; MIR-200; FAMILY; MESENCHYMAL TRANSITION; LUNG-CANCER; NEOPLASTIC TRANSFORMATION; HUMAN KERATINOCYTES; TARGET RECOGNITION; PROTEIN-SYNTHESIS; ARSENIC EXPOSURE;
D O I：
10.1016/j.fct.2016.02.012
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
MicroRNAs (miRNAs), an important component of epigenetic mechanisms of carcinogenesis, have been shown to play crucial roles in cancer initiation, metastasis, prognosis and responses to drug treatment and may serve as biomarkers for early diagnosis of cancer and tools for cancer therapy. Metal carcinogens, such as arsenic, cadmium, hexavalent chromium and nickel, are well-established human carcinogens causing various cancers upon long term exposure. However, the mechanism of metal carcinogenesis has not been well understood, which limits our capability to effectively diagnose and treat human cancers resulting from chronic metal carcinogen exposure. Over recent years, the role of miRNAs in metal carcinogenesis has been actively explored and a growing body of evidence indicates the critical involvement of miRNAs in metal carcinogenesis. This review aims to discuss recent studies showing that miRNAs play important roles in metal carcinogen-induced cell malignant transformation and tumorigenesis. Some thoughts for future further studies in this field are also presented. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：58 / 65
页数：8
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