Cutaneous Manifestations in Hepatitis C virus infection

Objective: To determine the nature and frequency of cutaneous manifestations in patients of Hepatitis C virus (HCV) infection. Methodology: One hundred HCV positive patients presenting at Dermatology department of Civil Hospital Karachi from January 2008 to December 2008 were enrolled and evaluated for cutaneous manifestations. Relevant data regarding history, physical examination including skin & its appendages and investigations (complete blood counts, liver function tests, Serum Anti HCV antibodies, ultrasound abdomen) were recorded and analyzed. Results: Out of 100 patients (43% males, 57% females) mean age 41 years (Range 12-70 years), pruritus was the most common dermatological feature seen in 35% patients followed by Lichen planus 12% and idiopathic thrombocytopenic purpura in 8% patients. Less common features were urticaria, alopecia areata, porphyria cutanea tarda & cryoglobulenemia. Conclusion: Pruritus, lichen planus and idiopathic thrombocypenic purpura are common Cutaneous manifestations in patients suffering from HCV infections. These are important and sometimes the only presenting feature of HCV infection, therefore health care providers should be vigilant while examining these patients for underlying HCV disease.