Circadian regulation of digestive and metabolic tissues

被引:6
|
作者
Taleb, Zainab [1 ]
Karpowicz, Phillip [1 ]
机构
[1] Univ Windsor, Dept Biomed Sci, Windsor, ON, Canada
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2022年 / 323卷 / 02期
基金
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词
adipose; circadian clock; circadian rhythm; digestion; metabolism; REV-ERB-ALPHA; CLOCK GENE-EXPRESSION; MULTIPLE INTESTINAL NEOPLASIA; INFLAMMATORY-BOWEL-DISEASE; MESSENGER-RNA EXPRESSION; BRUSH-BORDER ENZYMES; STEM-CELLS; ADIPOSE-TISSUE; SLEEP DURATION; DEOXYRIBONUCLEIC-ACID;
D O I
10.1152/ajpcell.00166.2022
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The circadian clock is a self-sustained molecular timekeeper that drives 24-h (circadian) rhythms in animals. The clock governs important aspects of behavior and physiology including wake/sleep activity cycles that regulate the activity of metabolic and digestive systems. Light/dark cycles (photoperiod) and cycles in the time of feeding synchronize the circadian clock to the surrounding environment, providing an anticipatory benefit that promotes digestive health. The availability of animal models targeting the genetic components of the circadian clock has made it possible to investigate the circadian clock's role in cellular functions. Circadian clock genes have been shown to regulate the physiological function of hepatocytes, gastrointestinal cells, and adipocytes; disruption of the circadian clock leads to the exacerbation of liver diseases and liver cancer, inflammatory bowel disease and colorectal cancer, and obesity. Previous findings provide strong evidence that the circadian clock plays an integral role in digestive/metabolic disease pathogenesis, hence, the circadian clock is a necessary component in metabolic and digestive health and homeostasis. Circadian rhythms and circadian clock function provide an opportunity to improve the prevention and treatment of digestive and metabolic diseases by aligning digestive system tissue with the 24-h day.
引用
收藏
页码:C306 / C321
页数:16
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