Long-Term Consumption of Anthocyanin-Rich Fruit Juice: Impact on Gut Microbiota and Antioxidant Markers in Lymphocytes of Healthy Males

被引:14
|
作者
Groh, Isabel Anna Maria [1 ,2 ]
Riva, Alessandra [3 ]
Braun, Dominik [1 ]
Sutherland, Heidi G. [4 ]
Williams, Owen [3 ]
Bakuradze, Tamara [5 ]
Pahlke, Gudrun [1 ]
Richling, Elke [5 ]
Haupt, Larisa M. [4 ]
Griffiths, Lyn R. [4 ]
Berry, David [3 ]
Marko, Doris [1 ]
机构
[1] Univ Vienna, Fac Chem, Dept Food Chem & Toxicol, Waehringerstr 38, A-1090 Vienna, Austria
[2] Univ Hosp Tuebingen, Dept Expt & Clin Pharmacol & Pharmacogenom, Div Pharmacogenom, Wilhelmstr 56, D-72074 Tubingen, Germany
[3] Univ Vienna, Dept Microbiol & Ecosyst Sci, Ctr Microbiol & Environm Syst Sci, Althanstr 14, A-1090 Vienna, Austria
[4] Univ Technol QUT Queensland, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Genom Res Ctr,Ctr Genom & Personalised Hlth, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia
[5] Univ Kaiserslautern, Dept Chem, Food Chem & Toxicol, Erwin Schroedinger Str 52, D-67663 Kaiserslautern, Germany
关键词
anthocyanin; intervention study; nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2); antioxidant effects; microbiota; TRANSCRIPTION FACTOR NRF2; GENE-TRANSCRIPTION; POLYPHENOLS; METABOLISM; DISCOVERY; SEQUENCES; OBESITY; TARGET; COFFEE; DIET;
D O I
10.3390/antiox10010027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polyphenols are considered protective against diseases associated with oxidative stress. Short-term intake of an anthocyanin-rich fruit juice resulted in significantly reduced deoxyribonucleic acid (DNA) strand-breaks in peripheral blood lymphocytes (PBLs) and affected antioxidant markers in healthy volunteers. Consequently, effects of long-term consumption of fruit juice are of particular interest. In focus was the impact on nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2), the Nrf2-regulated genes NAD(P)H quinone oxidoreductase 1 (NQO-1) and heme oxygenase 1 (HO-1) as well as effects on the gut microbiota. In a nine-week placebo-controlled intervention trial with 57 healthy male volunteers, consumption of anthocyanin-rich juice significantly increased NQO-1 and HO-1 transcript levels in PBLs compared to a placebo beverage as measured by real-time polymerase chain reaction (PCR). Three Nrf2-promotor single nucleotide polymorphisms (SNPs), analyzed by pyrosequencing, indicated an association between individual Nrf2 transcript levels and genotype. Moreover, the Nrf2 genotype appeared to correlate with the presence of specific microbial organisms identified by 16S-PCR and classified as Spirochaetaceae. Furthermore, the microbial community was significantly affected by the duration of juice consumption and intake of juice itself. Taken together, long-term consumption of anthocyanin-rich fruit juice affected Nrf2-dependent transcription in PBLs, indicating systemic effects. Individual Nrf2 genotypes may influence the antioxidant response, thus requiring consideration in future intervention studies focusing on the Nrf2 pathway. Anthocyanin-rich fruit juice had an extensive impact on the gut microbiota.
引用
收藏
页码:1 / 20
页数:18
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