Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial

被引：9
|
作者：
Roberto, Crocchiolo [1 ]
Clara, Cesana [1 ]
Debora, Girgenti [1 ]
Giambattista, Bertani [2 ]
Claudia, Barba [1 ]
Giuseppa, Liga [1 ]
Ursula, Ferri [1 ]
Lara, Crucitti [2 ]
Giovanni, Grillo [2 ]
Silvano, Rossini [1 ]
Roberto, Cairoli [2 ]
机构：
[1] ASST Grande Osped Metropolitano Niguarda, Serv Immunoematol & Med Trasfus, Piazza Osped Maggiore 3, I-20162 Milan, Italy
[2] ASST Grande Osped Metropolitano Niguarda, Ematol, Milan, Italy
来源：
EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2021年 / 10卷 / 01期
关键词：
Graft-versus-host disease; T regulatory cells; Extracorporeal photopheresis; Allogeneic hematopoietic stem cell transplantation;
D O I：
10.1186/s40164-021-00210-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of the present study was to evaluate the circulating T regulatory cells (Tregs) in patients undergoing extracorporeal photopheresis (ECP) for the prevention of chronic graft-versus-host disease (GvHD) and to search for any correlation between Tregs counts and chronic GvHD occurrence. Among n = 12 patients with complete longitudinal data, the median cumulative values of absolute peripheral Tregs counts were 21.64 and 63.49 cells/mu L for patients who developed chronic GvHD and those who did not develop it, respectively (p = 0.05). The analysis of the median absolute counts of peripheral HLA-DR + Tregs provided similar results, showing that 20% (1 out of 5) and 100% (7 out of 7) of patients with HLA-DR + Tregs values of > 5 cells/mu L were in the GvHD and non-GvHD groups, respectively (p = 0.01). In conclusion, the present results support the involvement of Tregs in the prevention of chronic GvHD in patients receiving ECP and suggest Tregs count as a potential biomarker of ECP effectiveness. Future strategies are needed to enhance Tregs expansion and/or activity in conjunction with ECP for an effective chronic GvHD prevention.
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页数：3
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