Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists:: Part IV

被引：8

作者：

Nakajima, Yutaka ^{[1
]}

Imanishi, Masashi ^{[1
]}

Itou, Shinji ^{[1
]}

Hamashima, Hitoshi ^{[1
]}

Tomishima, Yasuyo ^{[1
]}

Washizuka, Kenichi ^{[1
]}

Sakurai, Minoru ^{[1
]}

Matsui, Shigeo ^{[2
]}

Imamura, Emiko ^{[2
]}

Ueshima, Koji ^{[3
]}

Yamamoto, Takao ^{[2
]}

Yamamoto, Nobuhiro ^{[2
]}

Ishikawa, Hirofumi ^{[2
]}

Nakano, Keiko ^{[2
]}

Unami, Naoko ^{[2
]}

Hamada, Kaori ^{[2
]}

Hattori, Kouji ^{[1
]}

机构：

[1] Astellas Pharma Inc, Chem Res Labs, Tsukuba, Ibaraki 3058585, Japan

[2] Astellas Pharma Inc, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan

[3] Astellas Pharma Inc, Appl Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 18期

关键词：

beta(3)-adrenergic receptor agonist; overactive bladder;

D O I：

10.1016/j.bmcl.2008.08.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Identification and SAR study of novel series of beta(3)-AR agonists with benzoic acid are described. Conversion of ether linkage position of phenoxybenzoic acid derivative 2b led to compound 7b with moderate b(3)-AR activity. Further modi. cation in right, center and left parts of compound 7b was investigated to improve the b(3)-AR potency and selectivity. Compounds 7g and 7k, with the bulky aliphatic-substituted group at 2-position of benzoic acid moiety, were identified as potent and selective b(3)-AR agonists. In addition, in vivo efficacy of compounds 7g and 7k was exhibited on dog OAB model. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5037 / 5040

页数：4

共 40 条

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