DESTINATION: TEZEPELUMAB LONG-TERM SAFETY AND EFFICACY VERSUS PLACEBO IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA

被引:1
|
作者
Menzies-Gow, A. [1 ]
Wechsler, M. E. [2 ]
Brightling, C. E. [3 ]
Korn, S. [4 ,5 ]
Bednarczyk, A. [6 ]
Ponnarambil, S. [7 ]
Almqvist, G. [8 ]
Lawson, K. [9 ,10 ]
Caveney, S. [11 ]
Bowen, K. [12 ]
Colice, G. [9 ]
机构
[1] Royal Brompton & Harefield Hosp, London, England
[2] Natl Jewish Hlth, Denver, CO USA
[3] Univ Leicester, Inst Lung Hlth, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
[4] IKF Pneumol Mainz, Mainz, Germany
[5] Thoraxklin Heidelberg, Heidelberg, Germany
[6] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Warsaw, Poland
[7] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Cambridge, England
[8] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Gothenburg, Sweden
[9] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Gaithersburg, MD USA
[10] Cytel Inc, Cambridge, MA USA
[11] Amgen Inc, Global Dev, R&D, Thousand Oaks, CA USA
[12] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Biometr, Gaithersburg, MD USA
关键词
D O I
10.1136/thorax-2022-BTSabstracts.53
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
S47
引用
收藏
页码:A32 / A32
页数:1
相关论文
共 50 条
  • [41] Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
    Busse, William W.
    Bleecker, Eugene R.
    FitzGerald, J. Mark
    Ferguson, Gary T.
    Barker, Peter
    Sproule, Stephanie
    Olsson, Richard F.
    Martin, Ubaldo J.
    Goldman, Mitchell
    LANCET RESPIRATORY MEDICINE, 2019, 7 (01): : 46 - 59
  • [42] Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study
    Menzies-Gow, Andrew
    Bourdin, Arnaud
    Chupp, Geoffrey
    Israel, Elliot
    Hellqvist, Asa
    Hunter, Gillian
    Roseti, Stephanie L.
    Ambrose, Christopher S.
    Llanos, Jean-Pierre
    Cook, Bill
    Corren, Jonathan
    Colice, Gene
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2023, 131 (03) : 343 - +
  • [43] One-year safety and tolerability of tezepelumab in Japanese patients with severe uncontrolled asthma: results of the NOZOMI study
    Shinkai, Masaharu
    Ebisawa, Motohiro
    Fukushima, Yasushi
    Takeuchi, Satomi
    Okada, Hiroshi
    Tokiyo, Tatsuro
    Hayashi, Nobuya
    Takikawa, Mami
    Colice, Gene
    Almqvist, Gun
    JOURNAL OF ASTHMA, 2023, 60 (03) : 616 - 624
  • [44] Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis
    Lai, Tianwen
    Wang, Shaobin
    Xu, Zhiwei
    Zhang, Chao
    Zhao, Yun
    Hu, Yue
    Cao, Chao
    Ying, Songmin
    Chen, Zhihua
    Li, Wen
    Wu, Bin
    Shen, Huahao
    SCIENTIFIC REPORTS, 2015, 5
  • [45] Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
    Corren, Jonathan
    Menzies-Gow, Andrew
    Chupp, Geoffrey
    Israel, Elliot
    Korn, Stephanie
    Cook, Bill
    Ambrose, Christopher S.
    Hellqvist, Asa
    Roseti, Stephanie L.
    Molfino, Nestor A.
    Llanos, Jean-Pierre
    Martin, Neil
    Bowen, Karin
    Griffiths, Janet M.
    Parnes, Jane R.
    Colice, Gene
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 208 (01) : 13 - 24
  • [46] Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with Respiratory Comorbidities: Results from the Phase 3 NAVIGATOR Study
    Carr, Tara
    Bernstein, Jonathan
    Cook, Bill
    Hunter, Gillian
    Ambrose, Chris
    Llanos-Ackert, Jean-Pierre
    Lindsley, Andrew
    Colice, Gene
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 149 (02) : AB152 - AB152
  • [47] Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis
    Tianwen Lai
    Shaobin Wang
    Zhiwei Xu
    Chao Zhang
    Yun Zhao
    Yue Hu
    Chao Cao
    Songmin Ying
    Zhihua Chen
    Wen Li
    Bin Wu
    Huahao Shen
    Scientific Reports, 5
  • [48] Tezepelumab for Patients with Severe Uncontrolled Asthma: A Systematic Review and Meta-Analysis
    Zoumot, Zaid
    Al Busaidi, Nasser
    Tashkandi, Wail
    Aljohaney, Ahmed A.
    Isse, Said
    Vidyasagar, Kota
    Ukwaja, Kingsley Nnanna
    JOURNAL OF ASTHMA AND ALLERGY, 2022, 15 : 1665 - 1679
  • [49] Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction
    Israel, Elliot
    Castro, Mario
    Ambrose, Christopher S.
    Llanos, Jean-Pierre
    Molfino, Nestor A.
    Martin, Nicole L.
    Ponnarambil, Sandhia S.
    Martin, Neil
    ERJ OPEN RESEARCH, 2024, 10 (06)
  • [50] Tezepelumab Efficacy By SNOT-22 Score In Patients With Severe, Uncontrolled Asthma And Comorbid Nasal Polyps In NAVIGATOR
    Jacobs, Joshua
    Hoyte, Flavia
    Spahn, Joseph
    Ambrose, Chris
    Martin, Nicole
    Vong, Sylvia
    Caveney, Scott
    Cook, Bill
    Colice, Gene
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : AB17 - AB17