Immunogenicity, the elephant in the room. Comment on "Drug levels, anti-drug antibodies and clinical efficacy of the anti-TNFα biologics in rheumatic diseases"

被引：2
|
作者：
Pixley, John [1 ,2 ]
机构：
[1] Univ Nevada, Sch Med, Div Rheumatol, Reno, NV 89557 USA
[2] Univ VA Sierra Heath Care Syst, Div Immunol, Reno, NV USA
来源：
CLINICAL RHEUMATOLOGY | 2013年 / 32卷 / 10期
关键词：
ABATACEPT; ARTHRITIS;
D O I：
10.1007/s10067-013-2364-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1413 / 1413
页数：1
相关论文
共 50 条
  • [21] Relevance of anti-drug antibodies in context of supra-therapeutic anti-TNF concentrations
    Kim, J.
    Walshe, M.
    Borowski, K.
    Milgrom, R.
    Stempak, J.
    Lee, S. H.
    Croitoru, K.
    Silverberg, M. S.
    JOURNAL OF CROHNS & COLITIS, 2024, 18 : I933 - I934
  • [22] Anti-Drug Antibodies As a Predictor for the Discontinuation of Anti-TNF Agents in Patients with Spondyloarthrtis.
    Hwang, Jiwon
    Kim, In Young
    Lee, Seulkee
    Jeong, Hyemin
    Kim, Hyungjin
    Lee, Jaejoon
    Koh, Eun-mi
    Cha, Hoon-Suk
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S263 - S263
  • [23] Presence of Anti-drug Antibodies Does Not Reduce the Efficacy of an Oral Anti-TNF Antibody in a Murine IBD Model
    Bhol, Kailash
    Erlich, Emma
    Lemos, Brenda
    Tracey, Daniel
    Hartman, Deborah
    Fox, Barbara
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2013, 108 : S545 - S546
  • [24] Anti-TNF and Anti-Drug Antibodies Levels Predict the Outcomes of Interventions After Loss of Response to Adalimumab and Infliximab
    Yanai, Henit
    Lichtenstein, Lev
    Assa, Amit
    Mazor, Yoav
    Weiss, Batia
    Levine, Arie
    Ron, Yulia
    Kopylov, Uri
    Bujanover, Yoram
    Rosenbach, Yoram
    Ungar, Bella
    Eliakim, Abraham R.
    Chowers, Yehuda
    Shamir, Raanan
    Fraser, Gerald
    Dotan, Iris
    Ben-Horin, Shomron
    GASTROENTEROLOGY, 2014, 146 (05) : S381 - S381
  • [25] INTEREST IN THE ADDITION OF AZATHIOPRINE (AZA) TO THE SWITCH OF ANTI-TNF IN IBD PATIENTS IN CLINICAL RELAPSE WITH UNDETECTABLE ANTI-TNF TROUGH LEVELS AND ANTI-DRUG ANTIBODIES: A PROSPECTIVE RANDOMIZED TRIAL
    Roblin, Xavier
    Paul, Stephane
    Nancey, Stephane
    Williet, Nicolas
    Flourie, Bernard
    GASTROENTEROLOGY, 2018, 154 (06) : S84 - S84
  • [26] High level of anti-drug antibodies after intra-articular injection of anti-TNF
    Zufferey, Pascal
    Perreau, Mathieu
    So, Alexander
    RHEUMATOLOGY, 2015, 54 (12) : 2291 - 2292
  • [27] Clinical and laboratory markers associated with anti-TNF-alpha trough levels and anti-drug antibodies in patients with inflammatory bowel diseases
    Grinman, Ana B.
    de Souza, Maria das Gracas C.
    Bouskela, Eliete
    Carvalho, Ana Teresa P.
    de Souza, Heitor S. P.
    MEDICINE, 2020, 99 (10) : E19359
  • [28] Should anti-TNF-α drug levels and/or anti-drug antibodies be assayed in patients treated for rheumatoid arthritis?
    Mulleman, Denis
    Ducourau, Emilie
    Paintaud, Gilles
    Ternant, David
    Watier, Herve
    Goupille, Philippe
    JOINT BONE SPINE, 2012, 79 (02) : 109 - 112
  • [29] Quartz crystal microbalance as an assay to detect anti-drug antibodies for the immunogenicity assessment of therapeutic biologics
    Dubiel, Evan A.
    Fulop, Tamas
    Vigier, Sylvain
    Vermette, Patrick
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2017, 409 (30) : 7153 - 7167
  • [30] Quartz crystal microbalance as an assay to detect anti-drug antibodies for the immunogenicity assessment of therapeutic biologics
    Evan A. Dubiel
    Tamás Fülöp
    Sylvain Vigier
    Patrick Vermette
    Analytical and Bioanalytical Chemistry, 2017, 409 : 7153 - 7167
12345