Synthesis and biological activity of 2′,5′-oligoadenylate trimers containing 5′-terminal 5′-amino-5′-deoxy- and 5′-amino-3′,5′-dideoxyadenosine derivatives

被引：0

作者：

Kvasyuk, EI

Mikhailopulo, IA

Suhadolnik, RJ

Henderson, EE

Muto, NF

Iacono, KT

Homon, J

Pfleiderer, W

机构：

[1] Univ Konstanz, Fak Chem, D-78434 Constance, Germany

[2] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA

[3] Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USA

[4] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19140 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期

关键词：

D O I：

10.1080/07328319908044760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions, of HIV-1 reverse transcriptase (RT),HIV-1 induced syncytia formation and PCR amplification.

引用

页码：1483 / 1484

页数：2

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