Rhodium-Catalyzed Asymmetric Hydroformylation of 1,1-Disubstituted Allylphthalimides: A Catalytic Route to 3-Amino Acids

被引：21

作者：

Zheng, Xin ^{[1
,2
]}

Cao, Bonan ^{[1
,2
]}

Liu, Tang-lin ^{[3
]}

Zhang, Xumu ^{[1
,2
,3
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

[3] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 04期

基金：

美国国家科学基金会;

关键词：

allylphthalimides; 3-amino acids; 3-amino alcohols; 3-amino aldehydes; asymmetric catalysis; enantioselectivity; hydroformylation; rhodium; HIGHLY ENANTIOSELECTIVE HYDROFORMYLATION; DIASTEREOSELECTIVE HYDROFORMYLATION; OLEFINS; HYDROGENATION; LIGANDS; ETHERS; EFFICIENT; PEPTIDES; ALDEHYDE; AMINES;

D O I：

10.1002/adsc.201200960

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The high enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted allylphthalimides has been developed. By employing chiral ligand 1,2-bis[(2S,5S)-2,5-diphenylphospholano]ethane [(S,S)-Ph-BPE], a series of 3-aminoaldehydes can be prepared with up to 95% enantioselectivity. This asymmetric procedure provides an efficient alternative route to prepare chiral 3-amino acids and alcohols.

引用

页码：679 / 684

页数：6

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