Visualization of UV-induced damage on single DNA molecules

被引：26

作者：

Lee, Jinyong ^{[1
,2
]}

Park, Hyun Seung ^{[1
,2
]}

Lim, Sangyong ^{[3
]}

Jo, Kyubong ^{[1
,2
]}

机构：

[1] Sogang Univ, Dept Chem, Seoul 121742, South Korea

[2] Sogang Univ, Interdisciplinary Program Integrated Biotechnol, Seoul 121742, South Korea

[3] Korea Atom Energy Res Inst, Res Div Biotechnol, Jeongeup 580185, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 42期

基金：

新加坡国家研究基金会;

关键词：

ATOMIC-FORCE MICROSCOPY; RESOLUTION; SYSTEM; GENE;

D O I：

10.1039/c3cc38884k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ultraviolet radiation induced DNA damage such as double stranded breaks and single stranded breaks is visualized at the level of single DNA molecules. Molecular observations provide a map of DNA radiation-mediated breakages, revealing the sequence dependency of DNA damage rather than random occurrences.

引用

页码：4740 / 4742

页数：3

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