Multi-part balanced incomplete-block designs

被引：3

作者：

Bailey, R. A. ^{[1
,2
]}

Cameron, Peter J. ^{[1
,2
]}

机构：

[1] Univ St Andrews, Sch Math & Stat, St Andrews KY16 9SS, Fife, Scotland

[2] Queen Mary Univ London, Sch Math Sci, Mile End Rd, London E1 4NS, England

来源：

STATISTICAL PAPERS | 2019年 / 60卷 / 02期

关键词：

Balanced incomplete-block design; Basket trial; Multi-part design; Orthogonal array; Orthogonal multi-array; 2; SETS;

D O I：

10.1007/s00362-018-01071-x

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some consequences. Then we give several different constructions. Finally we generalize this to three or more factors, such as biomarkers.

引用

页码：55 / 76

页数：22

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