The relationship between allozyme and chromosomal polymorphism inferred from nucleotide variation at the Acph-1 gene region of Drosophila subobscura

被引:0
|
作者
Navarro-Sabaté, A [1 ]
Aguadé, M [1 ]
Segarra, C [1 ]
机构
[1] Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain
关键词
D O I
暂无
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Acph-1 gene region was sequenced in 51 lines of Drosophila subobscura. Lines differ in their chromosomal arrangement for segment I of the O chromosome (O-st and O3+4) and in the Acph-1 electrophoretic allele (Acph-1(100), Acph-1(054), and Acph-1(>100)). The ACPH-1 protein exhibits much more variation than previously detected by electrophoresis. The amino acid replacements responsible for the Acph-1(054) and Acph-1(>100) electrophoretic variants are different within O-st and within O3+4, which invalidates all previous studies on linkage disequilibrium between chromosomal and allozyme polymorphisms at this locus. The Acph-1(>100) allele within O3+4 has a recent origin, while both Acph-1(054) alleles are rather old. Levels of nucleotide variation are higher within the O3+4 than within the O-st arrangement except for nonsynonymous sites. The McDonald and Kreitman test shows a significant excess of nonsynonymous polymorphisms within O-st when D. guanche is used as the outgroup. According to the nearly neutral model of molecular evolution, this excess is consistent with a smaller effective size of O-st relative to O3+4 arrangements. A smaller population size, a lower recombination, and a more recent bottleneck might be contributing to the smaller effective size of O-st.
引用
收藏
页码:871 / 889
页数:19
相关论文
共 36 条
  • [21] Relationship between chromosomal races/subraces in the brachypterous grasshopper Podisma sapporensis (Orthoptera: Acrididae) inferred from mitochondrial ND2 and COI gene sequences
    Kowalczyk, Marek
    Tatsuta, Haruki
    Grzywacz, Beata
    Warchalowska-Sliwa, Elzbieta
    ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA, 2008, 101 (05) : 837 - 844
  • [22] Relationship between rs966221 Single Nucleotide Polymorphism of PDE4D Gene and Ischemic Stroke in Zhuang Population of Guangxi Zhuang Autonomous Region
    Jiang, D. D.
    Li, H. H.
    Li, J. L.
    Xiao, Y. S.
    Gan, L.
    Luo, M.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2018, 66 : S466 - S466
  • [23] RELATIONSHIP BETWEEN PAI-1 PROMOTOR REGION GENE 4G/5G POLYMORPHISM AND PULMONARY THROMBOEMBOLISM
    Ma Hanying
    Han Hong-ya
    Yang Qing
    Nie-Bin
    Liu Rui-fang
    Chai Meng
    Zhang Ou
    Guo Wen
    Zhou Yu-jie
    HEART, 2013, 99 : E65 - E65
  • [24] Relationship between Single Nucleotide Polymorphism in TNF-α Gene Promoter Region and Inhibitory Effects of Triptolide on TNF-α Production in Peripheral Blood Mononuclear Cells of Healthy Humans
    涂胜豪
    陈红波
    盛冬云
    胡永红
    刘沛霖
    华中科技大学学报(医学英德文版), 2006, (03) : 347 - 349
  • [25] Relationship between single nucleotide polymorphism in TNF-α gene promoter region and inibitory effects of triptolide on TNF-α production in peripheral blood mononuclear cells of healthy humans
    Tu Shenghao
    Chen Hongbo
    Sheng Dongyun
    Hu Yonghong
    Liu Peilin
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2006, 26 (3): : 347 - 349
  • [26] Determination of a possible relationship between a single nucleotide polymorpnism (SNP) in the promoter region of the SIRT1 gene and production and reproduction traits in the Agerolese cattle breed
    Selvaggi, Maria
    Carbonara, Claudia
    Ciotola, Francesca
    Albarella, Sara
    Aiudi, Giulio
    Tufarelli, Vincenzo
    Dario, Cataldo
    ARCHIVES ANIMAL BREEDING, 2019, 62 (01) : 107 - 112
  • [27] Frequency distribution of the single-nucleotide -108C/T polymorphism at the promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease
    Ahmad I.
    Narang R.
    Venkatraman A.
    Das N.
    Journal of Community Genetics, 2011, 2 (1) : 27 - 32
  • [28] The relationship between the TGF-β1 gene-509C/T polymorphism and tubulointerstitial damage resulting from primary nephrotic syndrome
    Li, Y.
    Liu, F. -Y.
    Peng, Y. -M.
    Li, J.
    Sun, L.
    Chen, X.
    Duan, S. -B.
    Ling, G. -H.
    Guo, N.
    Liu, Y. -H.
    RENAL FAILURE, 2010, 32 (04) : 420 - 427
  • [29] Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of the HLA-C Gene and Surface HLA-C Expression
    Corrah, Tumena W.
    Goonetilleke, Nilu
    Kopycinski, Jakub
    Deeks, Steven G.
    Cohen, Myron S.
    Borrow, Persephone
    McMichael, Andrew
    Brackenridge, Simon
    JOURNAL OF VIROLOGY, 2011, 85 (07) : 3367 - 3374
  • [30] Relationship Between the Single Nucleotide Polymorphism A35C in the Cu/Zn-Superoxide Dismutase-1 Gene and Glycemic Control in Individuals with Type 2 Diabetes Mellitus
    de Carvalho, Gabrielli Barbosa
    Brandao-Lima, Paula Nascimento
    Santos, Ramara Kadija Fonseca
    Rocha, Vivianne de Sousa
    Oliveira, Alan Santos
    Santos, Beatriz da Cruz
    Santos, Cynthia Batista
    Reis, Aline Rocha
    Maia, Carla Soraya Costa
    de Oliveira e Silva, Ana Mara
    Pires, Liliane Viana
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2025,