Recent advances in optogenetics and pharmacogenetics

被引:68
|
作者
Aston-Jones, Gary [1 ]
Deisseroth, Karl [2 ,3 ]
机构
[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA
关键词
Optogenetics; Pharmacogenetics; Channelrhodopsin; DREADD; Designer receptor; Viral transduction; Neurotransmitter signaling; Motivation/cognition; Autonomic function; Sensory function; Translational neuroscience; PROTEIN; FAMILY;
D O I
10.1016/j.brainres.2013.01.026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Optogenetics with microbial opsin genes, and pharmacogenetics with designer receptors, represent potent and versatile experimental modalities that can be integrated with each other as well as with a rich diversity of synergistic methods to provide fundamental opportunities in neuroscience research. The 7th Annual Brain Research Meeting in New Orleans in October 2012, Optogenetics and Pharmacogenetics in Neuronal Function and Dysfunction, brought together leading researchers that have developed and used these tools to explore a wide range of questions in nervous system function and dysfunction. This special issue of Brain Research includes articles by speakers in this meeting and others, which together synthesize and summarize the state of the art for optogenetics and designer receptors. This article is part of a Special Issue entitled Optogenetics (7th BRES) (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 50 条
  • [41] Advances and prospects of rhodopsin-based optogenetics in plant research
    Zhou, Yang
    Ding, Meiqi
    Nagel, Georg
    Konrad, Kai R.
    Gao, Shiqiang
    PLANT PHYSIOLOGY, 2021, 187 (02) : 572 - 589
  • [42] Pharmacogenetics of antipsychotics: recent progress and methodological issues
    Zhang, Jian-Ping
    Malhotra, Anil K.
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2013, 9 (02) : 183 - 191
  • [43] ADVANCES IN GENETICS AND PHARMACOGENETICS IN PSYCHIATRY: TOWARDS PRECISION MEDICINE
    Wray, N.
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2019, 53 : 5 - 5
  • [44] Advances to clinical application: Is pharmacogenetics ready for clinical application?
    Lee, Min-Soo
    ASIA-PACIFIC PSYCHIATRY, 2012, 4 : 42 - 42
  • [45] Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
    Sun, Yuwen
    Li, Manrui
    Cao, Shuqiang
    Xu, Yang
    Wu, Peiyan
    Xu, Shuting
    Pan, Qian
    Guo, Yadong
    Ye, Yi
    Wang, Zheng
    Dai, Hao
    Xie, Xiaoqi
    Chen, Xiameng
    Liang, Weibo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (03)
  • [46] RECENT ADVANCES
    LACOMBE, MA
    AMERICAN JOURNAL OF MEDICINE, 1990, 88 (04): : 407 - 408
  • [47] Recent Advances
    Guangya Chen
    Shengjie Li
    Jiuping Xu
    Xinmin Yang
    Journal of Optimization Theory and Applications, 2018, 177 : 603 - 605
  • [48] Recent Advances
    Chen, Guangya
    Li, Shengjie
    Xu, Jiuping
    Yang, Xinmin
    JOURNAL OF OPTIMIZATION THEORY AND APPLICATIONS, 2018, 177 (03) : 603 - 605
  • [49] RECENT ADVANCES
    不详
    JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1966, 197 (10): : 825 - &
  • [50] Optogenetics: Background, Methodological Advances and Potential Applications for Cardiovascular Research and Medicine
    Joshi, Jyotsna
    Rubart, Michael
    Zhu, Wuqiang
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 7 (07):