An Efficient Molecular Dynamics Simulation Strategy to Investigate the Mechanistic Basis for Biased Agonism at G Protein-Coupled Receptors

被引:0
|
作者
Meral, Derya [1 ]
Provasi, Davide [1 ]
Filizola, Marta [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Pharmacol Sci, New York, NY 10029 USA
关键词
D O I
10.1016/j.bpj.2017.11.1129
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
1018-Plat
引用
收藏
页码:202A / 202A
页数:1
相关论文
共 50 条
  • [21] Molecular dynamics techniques for modeling G protein-coupled receptors
    McRobb, Fiona M.
    Negri, Ana
    Beuming, Thijs
    Sherman, Woody
    CURRENT OPINION IN PHARMACOLOGY, 2016, 30 : 69 - 75
  • [22] Biased Signaling through G Protein-coupled Receptors
    Kurose, Hitoshi
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2022, 142 (10): : 1091 - 1101
  • [23] A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors
    Gundry, Jaimee
    Glenn, Rachel
    Alagesan, Priya
    Rajagopal, Sudarshan
    FRONTIERS IN NEUROSCIENCE, 2017, 11
  • [24] Allostery in G protein-coupled receptors investigated by molecular dynamics simulations
    Ribeiro, Joao Marcelo Lamim
    Filizola, Marta
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2019, 55 : 121 - 128
  • [25] Modeling G protein-coupled receptors in complex with biased agonists
    Costanzi, Stefano
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2014, 35 (06) : 277 - 283
  • [26] G protein-coupled receptors: the structural basis for their pharmacology
    Tate, C. G.
    Carpenter, B.
    Lebon, G.
    Leslie, A. G.
    Miller-Gallacher, J.
    Warne, T.
    FEBS JOURNAL, 2017, 284 : 15 - 16
  • [27] Molecular architecture of G protein-coupled receptors
    vanRhee, AM
    Jacobson, KA
    DRUG DEVELOPMENT RESEARCH, 1996, 37 (01) : 1 - 38
  • [28] Molecular pharmacology of G protein-coupled receptors
    Summers, R. J.
    BRITISH JOURNAL OF PHARMACOLOGY, 2016, 173 (20) : 2931 - 2933
  • [29] Molecular modelling of G protein-coupled receptors
    IJzerman, AP
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R399 - R399
  • [30] Molecular basis of inverse agonism in a G protein–coupled receptor
    Jean-Pierre Vilardaga
    Ralf Steinmeyer
    Greg S Harms
    Martin J Lohse
    Nature Chemical Biology, 2005, 1 : 25 - 28