Pectin: A Long-Neglected Broad-Spectrum Antibacterial

被引:70
|
作者
Ciriminna, Rosaria [1 ]
Fidalgo, Alexandra [2 ,3 ]
Meneguzzo, Francesco [4 ]
Presentato, Alessandro [5 ]
Scurria, Antonino [1 ]
Nuzzo, Domenico [6 ]
Alduina, Rosa [5 ]
Ilharco, Laura M. [2 ,3 ]
Pagliaro, Mario [1 ]
机构
[1] CNR, Ist Studio Mat Nanostrutturati, Via U La Malfa 153, I-90146 Palermo, Italy
[2] Univ Lisbon, Inst Super Tecn, Ctr Quim Fis Mol, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
[3] Univ Lisbon, Inst Super Tecn, IN Inst Nanosci & Nanotechnol, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
[4] Ist Bioecon, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy
[5] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, I-90028 Palermo, Italy
[6] CNR, Ist Ric & Innovaz Biomed, Via U La Malfa 153, I-90146 Palermo, Italy
关键词
antibacterial agents; antimicrobial agents; citrus pectin; pectin; polysaccharides; ANTIMICROBIAL ACTION; CITRUS PECTIN; EXTRACTION; ORANGE; AGENT;
D O I
10.1002/cmdc.202000518
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering.
引用
收藏
页码:2228 / 2235
页数:8
相关论文
共 50 条
  • [41] BROAD-SPECTRUM REDEFINED
    ARCHER, JR
    HEWSON, GE
    GORRINGE, JA
    LANCET, 1963, 2 (731): : 890 - &
  • [42] An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members
    Zhang, Peng-Li
    Laiche, Mouna Hind
    Li, Yan-Liang
    Gao, Wei-Wei
    Lin, Jian-Mei
    Zhou, Cheng-He
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 241
  • [43] BROAD-SPECTRUM PHOTOSENSOR
    Wilson, Elizabeth
    CHEMICAL & ENGINEERING NEWS, 2009, 87 (33) : 10 - 10
  • [44] A SPECIALIST WITH A BROAD-SPECTRUM
    ADAM, D
    MUNCHENER MEDIZINISCHE WOCHENSCHRIFT, 1982, 124 (36): : A102 - A104
  • [45] Broad-spectrum antivirals
    Edagwa, Benson J.
    Gendelman, Howard E.
    NATURE MATERIALS, 2018, 17 (02) : 114 - 116
  • [46] BROAD-SPECTRUM ANTIBIOTICS
    不详
    BMJ-BRITISH MEDICAL JOURNAL, 1963, (534): : 1276 - +
  • [47] BROAD-SPECTRUM ANTIHELMINTHAGOGUES
    KRAMPITZ, HE
    HAUTARZT, 1979, 30 (07): : 405 - 405
  • [48] Broad-spectrum antivirals
    Benson J. Edagwa
    Howard E. Gendelman
    Nature Materials, 2018, 17 : 114 - 116
  • [49] Polyurethane-coated silica particles with broad-spectrum antibacterial properties
    Xu, Qingxing
    Sardon, Haritz
    Chan, Julian M. W.
    Hedrick, James L.
    Yang, Yi Yan
    POLYMER CHEMISTRY, 2015, 6 (11) : 2011 - 2022
  • [50] A BROAD-SPECTRUM PENICILLIN
    不详
    BMJ-BRITISH MEDICAL JOURNAL, 1961, 2 (5246): : 223 - +